If you are taking any prescription medication, you have a medical condition or you have specific concerns about the suitability of any of our products in relation to these, you should always consult your GP or Pharmacist prior to taking supplements.
A one-year trial to assess the value of orlistat in the management of obesity.
Vitamin D is also needed for the normal development and growth of muscle fibers. Here’s what some of the latest research suggests about how the vitamin may affect certain chronic conditions. [, Crowe M, Wollner L, Griffiths RA. [, Marrie RA, Beck CA. Bone is constantly being remodeled. The USPSTF also reviewed the seven published studies on the effects of vitamin D supplementation (two of them also included calcium supplementation) on the risk of falls in community-dwelling adults aged 65 years or older who did not have osteoporosis or vitamin D deficiency. 5. Assessing the vitamin D status of the US population.
Ultra Vitamin D 400IU An everyday, recommended level of vitamin D Vitamin D contributes to the normal function of the immune system Ultra Vitamin D provides D3, which is the preferred form of vitamin D UK’s No.1 vitamin D brand Vitamin D supplementation and risk of toxicity in pediatrics: A review of current literature.
Considerations in dietetic counseling for vitamin D. J Acad Nutr Diet 2019;119:901-9.
J Clin Endocrinol Metab 2011;96:3838-45.
CMAJ 2019;191:E390-4. [, Creo AL, Thacher TD, Pettifor JM, Strand MA, Ficsher PR.
AskMayoExpert. Vitamin D2 is manufactured using UV irradiation of ergosterol in yeast, and vitamin D3 is produced with irradiation of 7-dehydrocholesterol from lanolin and the chemical conversion of cholesterol . Vitamin D helps regulate the renin-angiotensin-aldosterone system (and thereby blood pressure), vascular cell growth, and inflammatory and fibrotic pathways . Women with 25(OH)D levels of less than 30 nmol/L (12 ng/mL) had a 43% higher MS risk than women with levels of 50 nmol/L (20 ng/mL) or higher. Vitamin D and multiple sclerosis: A comprehensive review. Nutrients 2018, 10, 953.
[, Buckley LM, Leib ES, Cartularo KS, Vacek PM, Cooper SM. Am J Cardiol 2007;99:903-5. [, Herrick KA, Storandt RJ, Afful J, Pfeiffer CM, Schleicher RL, Gahche JJ, Potischman N. Vitamin D status in the United States, 2011-2014. Am J Clin Nutr 2014;100:746-55. [, Rafiq S, Jeppesen PB.
Observational studies indicate that greater body weights are associated with lower vitamin D status, and obese individuals frequently have marginal or deficient circulating 25(OH)D levels . Vitamin D supplementation has no effect on insulin sensitivity or secretion in vitamin D-deficient, overweight or obese adults: A randomized placebo-controlled trial. The importance of body weight for the dose response relationship of oral vitamin D supplementation and serum 25-hydroxyvitamin D in healthy volunteers.
Many genes encoding proteins that regulate cell proliferation, differentiation, and apoptosis are modulated in part by vitamin D. Many tissues have vitamin D receptors, and some convert 25(OH)D to 1,25(OH)2D. On average, men weigh more than women. They also help reduce fracture rates in institutionalized older people. Lancet Diabetes-Endocrinol 2014;2:719-29. the elderly population, whose skin may not be able to synthesise vitamin D as effectively. Bone health also depends on support from the surrounding muscles to assist with balance and postural sway and thereby reduce the risk of falling. Both forms raise serum 25(OH)D levels, and they seem to have equivalent ability to cure rickets . Among postmenopausal women and older men, many clinical trials have shown that supplements of both vitamin D and calcium result in small increases in bone mineral density throughout the skeleton [1,75].
In addition to bone deformities and pain, severe rickets can cause failure to thrive, developmental delay, hypocalcemic seizures, tetanic spasms, cardiomyopathy, and dental abnormalities [46,47]. However, other, shorter (from 24 weeks to 5 years) clinical trials of vitamin D supplementation alone or with calcium in adults found greater risks of hypercalcemia and hypercalciuria, but not of kidney stones [162,163].
[, Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, et al. Nutrients 2018; 10, 375; doi:10.3390/nu10030375 [, Mousa A, Naderpoor N, Teede H, Scragg R, de Courten, B. Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. No studies have evaluated whether vitamin D supplements may benefit individuals under medical care for clinical depression who have low or deficient 25(OH)D levels and are taking antidepressant medication. Although 25(OH)D functions as a biomarker of exposure, the extent to which 25(OH)D levels also serve as a biomarker of effect on the body (i.e., relating to health status or outcomes) is not clear [1,3]. The Food Standards Agency recommends that if you are pregnant or breastfeeding you should take a 400iu/ 10µg supplement of Vitamin D each day. Neurology 2012;79:2140-5.
There are several reasons why vitamin D supplementation may be especially recommended, including: * Contains Vitamin D3 (cholecalciferol), the preferred form of vitamin D produced naturally by the body on exposure to sunlight. Very limited evidence suggests no substantial differences in the bioavailability of vitamin D from various foods . However, the relative amount of body fat an individual has may be more pertinent, since vitamin D is stored in body fat. Food supplements must not replace a varied and balanced diet and a healthy lifestyle. The effect of vitamin D supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis. (6) The CDC points out that a vitamin D deficiency may lead to rickets, a rare condition in Western countries but one that can cause growth delays. Four percent had levels higher than 125 nmol/L (50 ng/mL). Vitamin D supplements and muscle function Simply Supplements work with industry-leading suppliers to obtain the finest quality vitamin D2 ingredients for use in this supplement, ensuring that you receive the best care and support. [, Sempos CT, Binkley N. 25-hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis.
Another thing to keep in mind is that the Food and Drug Administration doesn’t regulate supplements like it does over-the-counter medication and prescription medication.
In 2013–2014, an estimated 3.2% of the U.S. adult population took supplements containing 100 mcg (4,000 IU) or more vitamin D . [, Chakhtoura MT, Nakhoul N, Akl EA, Mantzoros CS, El Hajj Guleihan GA. Vitamin D deficiency. Maltodextrin, Bulking Agent: Microcrystalline Cellulose, Vitamin D3 (Cholecalciferol [Carriers: Sucrose, Acacia, Corn Starch, Medium Chain Triglycerides, Antioxidant: DL-Alpha Tocopherol]), Tablet Coating (Hydroxypropylmethylcellulose, Glycerin, Colour: Titanium Dioxide), Anti-Caking Agents: Silicon Dioxide, Stearic Acid & Magnesium Stearate. An analysis of NHANES 2011–2014 data on serum 25(OH)D levels found that most people in the United States aged 1 year and older had sufficient vitamin D intakes according to the FNB thresholds . Holick MF. These values, which vary by age and sex, include: An FNB committee established RDAs for vitamin D to indicate daily intakes sufficient to maintain bone health and normal calcium metabolism in healthy people. The trials administered different amounts of vitamin D (ranging from 10 mcg [400 IU]/day to 1,000 mcg [40,000 IU]/week). Clinical trials, however, do not support these findings. The second trial included 155 adults aged 60–80 years who had clinically relevant depressive symptoms, no major depressive disorder, and serum 25(OH)D levels less than 50 to 70 nmol/L (20 to 28 ng/mL) depending on the season; in addition, they were not taking antidepressants [133,134].
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